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DTSTART:20120217T180000Z
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SUMMARY:Neuroscience Seminar - Dr. S. Mulligan\, Feb. 17\, 2012
LOCATION:Physiology Conference Room\, 431 BMSB Bannatyne Campus
ORGANIZER;CN=Kelly Jorundson:MAILTO:wcsn@sbrc.ca
URL:http://www.scrc.umanitoba.ca/news/?id+20120206wcsn.txt
DESCRIPTION:Everyone is invited...\n\n Hosted by the Division of Neurodege
 nerative Disorders at St. Boniface Hospital Research\n Invited Speaker:  
 Dr. Sean Mulligan\n\nFriday\, February 17th\, 2012\n12:00 - 1:00 p.m.\nPh
 ysiology Conference Room\, 431 BMSB Bannatyne Campus\n\nDr. Sean Mulligan
 \nAssistant Professor\,\nDepartment of Physiology\, University of Saskatc
 hewan\n\nTopic: Functional Optical Imaging in Free Nerve Endings: A Pain 
 in the Dura.\n\nResearch Interests: Pain sensitivity within the skull is 
 restricted to\nthe intracranial meninges\, the system of membranes that e
 nvelops the\nbrain. Afferent thinly myelinated A&#948\;-fibres and unmyel
 inated C-fibres\nthat originate from the trigeminal ganglion densely inne
 rvate the\nmeninges\, in particular the cranial dura mater. It is widely 
 recognized\nthat activation or sensitization of these dural nociceptive a
 fferents is\nresponsible for the genesis of migraine headaches. However\,
  any details\nof the pathophysiological mechanisms involved are largely s
 peculative\nand remain to be discovered. Identification of the underlying
  mechanisms\nof activation of dural nociceptors may have important implic
 ations for\nunderstanding and mitigating the pathogenesis of migraine hea
 daches. We\nhave developed a novel en bloc dural-skull preparation that a
 llows\nus for the first time to apply optical imaging techniques to direc
 tly\nstudy with high resolution the free nerve endings and terminals of t
 he\nnociceptive fibres that terminate in the dura mater. The objective of
  our\nresearch is to gain insight into the neurophysiology of peripheral 
 pain\nactivation to better understand the pathophysiological processes th
 at\noccur during migraine headache. It is our hope that this will lead to
 \nnew peripheral drug targets and offer additional therapeutic treatments
 \nfor this devastating illness.\n\nFor more information\, contact:\nKelly
  Jorundson\nWinnipeg Chapter Society for Neuroscience\nT:  204.235.3939  
 F:  204.237.4092\nE-mail: wcsn@sbrc.ca
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